I: Lactoferrin Structure and Function. - 1. Lactoferrin Structure-Function Relationships: An Overview. - 2. Altered Domain Closure and Iron Binding in Lactoferrin Mutants. - 3. Affinity Mass Spectrometry: Probes with Surfaces Enhanced for Affinity Capture (SEAC) of Lactoferrin. - II: Lactoferrin Gene Expression. - 4. Variants and Biotechnological Use of the Bovine Lactoferrin-Encoding Gene. - 5. Posttranscriptional Regulation of Bovine and Human Lactoferrin: Species Differences and Influence of mRNA Regions. - 6. Mutagenesis of Human Lactoferrin and Expression in Baby Hamster Kidney Cells. - 7. Structural Determination of Two N-Linked Glycans Isolated from Recombinant Human Lactoferrin Expressed in BHK Cells. - 8. Distribution of the Iron-Binding Protein Lactof errin in the Pathological Lesions of Neurodegenerative Diseases. - 9. Lactoferrin Almost Absent from Lactating Rat Mammary Gland Is Replaced by Transferrin. - 10. Estrogen Regulation of Human Lactoferrin Gene Activity: Transcriptional Synergism Between Estrogen Receptorand Related Orphan Receptor. - 11. Expression and Functional Analysis of Recombinant Human Lactoferrin. - 12. Structural and Functional Flexibility of Lactoferrin. - 13. Difference in Binding and Fate of Lactotransferrin in Jurkat Human Lymphoblastic T-Cells and in T-47D Human Breast Cancer Cells. - 14. The Impact of Phagocyte-Lactoferrin Interactions on Inflammation. - 15. Regulation of Lymphocyte Proliferation by Lactoferrin. - 16. Recombinant Human Lactoferrin and Its Variants: Receptor Binding in Human Intestinal Brush-Border Membranes. - III: Functions Related to Lactoferrin Interactions with Prokaryotic and Eukaryotic Cells. - 17. Influence of Lactoferrin on HostMicrobe Interactions. - 18. Bacterial Lactoferrin Receptors in the Neisseriaceae. - 19. Bacteriostatic Effects of Orally Administered Bovine Lactoferrin on Intestinal Bacteria in the Gut of Mice Fed Bovine Milk. - 20. Functional Significance of the Binding of Lactoferrin to DNA. - 21. Specific Binding of Ferrilactoferrin and Ferritransf errin in the Protozoan Leishmania chagasi. - IV: Lactoferrin Metabolism. - 22. Observations on the Metabolism and Cellular Interactions of Lactoferrin. - 23. Lactoferrin as a Possible Transcriptional Regulator: Downmodulation of the Granulocyte-Macrophage Colony-Stimulating Factor Promoter. - V: The Use of Lactoferrin as a Food Additive. - 24. Modification of Infant Formula: The Case of Lactoferrin. - 25. Lactoferrin in Infant Formulas: How and Why?. Language: English